breast cancer

Research Papers

A Randomized Controlled Trial of Brief Mindfulness Meditation for Women Undergoing Stereotactic Breast Biopsy

Ratcliff, Chelsea G., Prinsloo, Sarah, Chaoul, Alejandro, Zepeda, Stephanie G., Cannon, Rex, Spelman, Amy, Yang, Wei T., Cohen, Lorenzo (2019) · Journal of the American College of Radiology: JACR

PURPOSE: Stereotactic breast biopsy (SBB) is a common, anxiety-producing procedure. Nonpharmacologic methods to manage acute anxiety are needed. METHODS: In this single-blind trial, women were recruited before SBB and randomized in a 2:2:1 ratio to a single session of guided mindfulness-based meditation (GM; n = 30), focused breathing (FB; n = 30), or standard care (SC; n = 16). Anxiety and pain were assessed at baseline after a 10-min prebiopsy group-specific activity (GM, FB, or SC), every 4 min during SBB, and after biopsy. Electroencephalographic activity in the medial prefrontal cortex, insula, anterior cingulate cortex, and precuneus was collected throughout the study. RESULTS: Women in the GM group reported a steeper reduction in anxiety than women in the FB and SC groups (P < .001 for all, Cohen's d > 0.4 for all). There were no group differences in pain ratings during the biopsy. Women in the GM group experienced increased beta activity during biopsy in the insula (P = .006, Cohen's d = 1.4) and anterior cingulate cortex (P = .019, Cohen's d = 1.0) compared with women in the SC group, and there was a trend toward the same effect compared with women in the FB group (P < .10 for both). Women in the GM and FB groups experienced a nonsignificant decrease in delta activity in the precuneus during biopsy compared with those in the SC group (P < .40 for both, Cohen's d > 0.6 for both), which was associated with a steeper reduction in anxiety during the biopsy (r = 0.51, P < .01). CONCLUSIONS: Brief, guided meditation may provide effective anxiety relief during an acute medical procedure and affect neuronal activity in regions associated with attention, self-awareness, and emotion regulation.

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Treating Post Chemotherapy Symptoms with Neurofeedback

Longo, Robert, Helfand, David (2016) · NeuroRegulation

Treatment for cancer often involves surgery, chemotherapy, and/or radiation. As a result of these interventions, studies have found that patients often experience prolonged side effects posttreatment. This case study focuses on a 62-year-old woman who was diagnosed with breast cancer and underwent surgery and chemotherapy. The patient was treated with 30 sessions of neurofeedback over the course of 2 weeks. Utilizing a combination of three different neurofeedback protocols, the patient reported significant improvements in cognitive and physical functioning.

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